Sepsis overview

Which of the following statements is an accurate definition of sepsis according to the most recent guidelines?

1: Infection leading to hyperthermia or hypothermia with leukocytosis or leukopenia only
2: Life-threatening organ dysfunction due to a dysregulated host response to an infection
3: Infection causing tachycardia and hypotension without other systemic symptoms
4: A severe inflammatory response resulting in fever and at least one organ failing