Lab evaluation of liver injury hyperbilirubinemia

A 14-year-old boy is admitted for evaluation of jaundice, dark urine, and pale stools. His total bilirubin level is 7.0 mg/dL and his direct bilirubin level is 5.0 mg/dL. A liver biopsy specimen has a grossly black appearance and histological examination shows pigmented granules within the hepatocytes. Which of the following statements about this patient’s condition is most accurate?

1: The Aspartate aminotransferase (AST) to Alanine aminotransferase (ALT): ratio will be greater than 2.
2: The patient has a mutation of intrahepatic bile duct membrane proteins.
3: This condition is the most common indication for liver transplant in children.
4: This is an autosomal dominant condition.