Hypothalamic pituitary dysfunction clinical manifestations

Which of the following answer choices correctly outlines the diagnostic criteria of secondary hypogonadism?

1: Absent menses by age 16 years in females and lack of testicular volume increase by age 14 in males. Low serum testosterone (males) or estradiol (females)
2: Minimal pubic, axillary, (and facial hair growth) by age 16 in either sex and low serum testosterone (males) or estradiol (females)
3: Small testes (less than 4 mL volume) in boys over the age of 14 years or absent breast buds in girls over the age of 12
4: Small testes (less than 4 mL volume) in boys over the age of 14 years or absent breast buds in girls over the age of 12. Low serum LH and FSH levels.