Cystic fibrosis management

What CFTR modulator therapy combination is typically used for patients 12 years or older with at least one delta F508 mutation?

1: Lumacaftor and Ivacaftor
2: Tezacaftor and Ivacaftor
3: Elexacaftor, Tezacaftor, and Ivacaftor
4: Ivacaftor monotherapy