Chloramphenicol

Which of the following correctly describes the mechanism of action of chloramphenicol?

1: It binds to the 80S subunit of the bacterial ribosome and inhibits protein synthesis.
2: It binds to the 50S subunit of the bacterial ribosome and inhibits peptide bond formation.
3: It binds to PBPs on the bacterial cell membrane and inhibits bacterial cell wall synthesis.
4: It binds to dihydropteroate synthase in the bacterial cytoplasm and interferes with bacterial folic acid synthesis.